TASCAM US-600 (6x4 USB2 Interface)
If you're looking for an all-around audio and MIDI interface with plenty of I/O, the TASCAM US-600 is a great pick.
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As low as $149.99 out of 2 sellers
User Review: I have gone through my fair share of both USB and FireWire interfaces in the last few years and this one is by far the best.